“Extracorporeal shock wave therapy (ESWT) has been shown to induce different biological effects on a variety of cells, including regulation and stimulation of their function and metabolism. ESWT can promote different biological responses such as proliferation, migration, and regenerations of cells.”1
“Recent studies have shown that mesenchymal stromal cells (MSCs) secrete factors that enhance the regeneration of tissues, stimulate proliferation and differentiation of cells, and decrease inflammatory and immune reactions. Clinically, the combination of these two therapies has been used as a treatment for tendon and ligament lesions in horses; however, there is no scientific evidence supporting this combination of therapies in vivo.”2
“In the present study, it was demonstrated that equine CB-MSCs respond to ESWT stimulation. The proliferation of these cells was not adversely influenced by shockwave treatment, but the metabolic activity of the treated cells was increased. This increased metabolic activity observed in equine CB-MSCs after ESWT is in agreement with other studies that reported increased proliferation, migration, and metabolic activity of human and rat ASCs. Treated cells do not only maintain but also increase their potency toward adipogenic and osteogenic lineages. There is growing evidence suggesting that ESWT has an effect on MSCs differentiation.
“Until now, only one experiment reported the combination of equine MSCs and ESWT in vitro; the authors reported that shockwaves stimulate adipose derived stem cells to a higher potential for differentiation toward adipogenic, osteogenic and chondrogenic lineages. As cell signaling studies have shown, same types of cells respond differently to the same stimulus, we believe this variation in response to treatment to be the reason why MSCs from different sources, have a different biological behavior after ESWT.”
https://www.frontiersin.org/articles/10.3389/fvets.2020.554306/full https://www.thieme-connect.de/products/ejournals/abstract/10.3415/VCOT-15-04-0057
